Welcome to the Amira-Avizo Software Use Case Gallery

Below you will find a collection of use cases of our 3D data visualization and analysis software. These use cases include scientific publications, articles, papers, posters, presentations or even videos that show how Amira-Avizo Software is used to address various scientific and industrial research topics.

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Micron-scale crack propagation in laser-irradiated enamel and dentine studied with nano-CT

Micron-scale crack propagation in laser-irradiated enamel and dentine studied with nano-CT

The aim of this study was to see the effect of Er:YAG laser irradiation in dentine and compare this with its effect in enamel. The mechanism of crack propagation in dentine was emphasised and its clinical implications were discussed. A possible mechanism is that laser radiation is transmitted down the dentinal tubules causing micro-cracks to form in the dentinal tubule walls that tend to be limited to this region. Crack might be a source of fracture as it represents a weak point and subsequen... Read more

Abtesam Aljdaimi, Hugh Devlin, Mark Dickinson, Timothy Burnett, Thomas J. A. Slater

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Revisiting the lacquer peels method with pyroclastic deposits: sediment plates, a precise, fine scale imaging method and powerful outreach tool

Revisiting the lacquer peels method with pyroclastic deposits: sediment plates, a precise, fine scale imaging method and powerful outreach tool

Sediment plates (a type of lacquer peels) represent a sampling method whereby a thin plate of undisturbed sediments is obtained directly from the outcrop. A low-viscosity, hardening epoxy resin is applied to a freshly exposed cross-section of an unconsolidated deposit and impregnates a surface layer of the cross-section via capillary forces before solidifying. Upon hardening, a solid plate (0.5–5 cm thick and up to 2 m in length) of the sedimentary formation can be recovered and transported... Read more

Guilhem Amin Douillet, Ulrich Kueppers, Célia Mato, Quentin Chaffaut, Mélanie Bouysson, Renate Reschetizka, Inga Hoelscher, Patrick Witting, Kai-Uwe Hess, Alexander Cerwenka, Donald B Dingwell and Benjamin Bernard

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Oldest skeleton of a fossil flying squirrel casts new light on the phylogeny of the group

Oldest skeleton of a fossil flying squirrel casts new light on the phylogeny of the group

Here we report the oldest fossil skeleton of a flying squirrel (11.6 Ma) that displays the gliding-related diagnostic features shared by extant forms and allows for a recalibration of the divergence time between tree and flying squirrels. Our phylogenetic analyses combining morphological and molecular data generally support older dates than previous molecular estimates (~23 Ma), being congruent with the inclusion of some of the earliest fossils (~36 Ma) into this clade. They also show that fl... Read more

Isaac Casanovas-Vilar, Joan Garcia-Porta, Josep Fortuny, Oscar Sanisidro, Jerome Prieto, Marina Querejeta, Sergio Llacer, Josep M Robles, Federico Bernardini, David M Alba

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Investigation of pressure drop in 3D replicated open-cell foams: Coupling CFD with experimental data on additively manufactured foams

Investigation of pressure drop in 3D replicated open-cell foams: Coupling CFD with experimental data on additively manufactured foams

Open-cell foams as structured catalyst supports are promising candidates for the design of high throughput catalytic processes. In this contribution, we employ a coupled numerical and experimental approach to assess the pressure losses in foams. (…) we explore virtually-generated foam models and their 3D printed replicas for a combined CFD and experimental study of fluid dynamics in foams. In particular, we focus our analysis on the low Reynolds number regime, where deviations between t... Read more

Mauro Bracconi, Matteo Ambrosetti, Obinna Okafor, Victor Sans, Xun Zhang, Xiaoxia Ou, Claudio Pereira Da Fonte, Xiaolei Fan, Matteo Maestri, Gianpiero Groppi, Enrico Tronconi

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Vascular structure of the earliest shark teeth

Vascular structure of the earliest shark teeth

Here we use synchrotron tomography to characterise dental vasculature in the oldest known tooth-bearing sharks, Leonodus carlsi Mader, 1986 and Celtiberina maderi Wang, 1993. Three dimensional reconstruction of the vascular system and microstructure of both taxa revealed a complex and dense network of canals, including horizontal, ascending and secondary bifurcated canals, as well as histological features consistent with an osteodont histotype. However, L. carlsi and C. maderi also exhibit si... Read more

Carlos Martinez-Perez, Alba Martin-Lazaro, Humberto G Ferron, Martina Kirstein, Philip C.J. Donoghue, Hector Botella

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Branching morphogenesis of the urinary collecting system in the human embryonic metanephros

Branching morphogenesis of the urinary collecting system in the human embryonic metanephros

An elaborate system of ducts collects urine from all nephrons, and this structure is known as the urinary collecting system (UCS). This study focused on how the UCS is formed during human embryogenesis. Fifty human embryos between the Carnegie stage (CS) 14 and CS23 were selected from the Kyoto Collection at the Congenital Anomaly Research Center of Kyoto University, Japan. Metanephroses, including the UCS, were segmented on serial digital virtual histological sections. Three-dimensional imag... Read more

Hana Ishiyama, Aoi Ishikawa, Haruka Kitazawa, Sena Fujii, Jun Matsubayashi, Shigehito Yamada, Tetsuya Takakuwa

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Nonuniformity in ligaments is a structural strategy for optimizing functionality

Nonuniformity in ligaments is a structural strategy for optimizing functionality

Ligaments serve as compliant connectors between hard tissues. In that role, they function under various load regimes and directions. The 3D structure of ligaments is considered to form as a uniform entity that changes due to function. The periodontal ligament (PDL) connects the tooth to the bone and sustains different types of loads in various directions. Using the PDL as a model, employing a fabricated motorized setup in a microCT, we demonstrate that the fibrous network structure with... Read more

Gili R. S. Naveh, Jonathan E. Foster, Tomas M. Silva Santisteban, Xianrui Yang, and Bjorn R. Olsen

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Functional Electrical Stimulation Leads to Increased Volume of the Aged Thyroarytenoid Muscle

Functional Electrical Stimulation Leads to Increased Volume of the Aged Thyroarytenoid Muscle

A stimulation electrode was placed unilaterally near the terminal adduction branch of the recurrent laryngeal nerve (RLN) adjacent to the right cricothyroid joint. The electrode was connected to an implant located subcutaneously at the neck region. Predesigned training patterns were automatically delivered by a bidirectional radio frequency link using a programming device and were repeated automatically by the implant every other day over 11 weeks in the awake animal. Outcome parameters compr... Read more

Markus Gugatschka, MD, DMSci, Jonathan C. Jarvis, PhD, Justin D. Perkins, MSc, Vladimir Bubalo, PhD, Iris Wiederstein-Grasser, PhD, Hermann Lanmüller, PhD, Claus Gerstenberger, MSc and Michael Karbiener, PhD

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Three-dimensional Image Based Modelling of Transport Parameters in LithiumSulfur Batteries

Three-dimensional Image Based Modelling of Transport Parameters in LithiumSulfur Batteries

An elemental sulfur electrode was imaged with X-ray micro and nano computed tomography and segmented into its constituent phases. Morphological parameters including phase fractions, pore and particle size distributions were calculated directly from labelled image data, and flux based simulations were performed to determine the effective molecular diffusivity of the pore phase and electrical conductivity of the conductive carbon and binder phase, Deff and σeff, that can be used as an input fo... Read more

Chun Tan, Matthew D. R. Kok, Sohrab R. Daemi, Dan Brett and Paul Shearing

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New omomyoids (Euprimates, Mammalia) from the late Uintan of southern California, USA, and the question of the extinction of the Paromomyidae (Plesiadapiformes, Primates)

New omomyoids (Euprimates, Mammalia) from the late Uintan of southern California, USA, and the question of the extinction of the Paromomyidae (Plesiadapiformes, Primates)

Paromomyidae has been thought to represent the longest-lived group of stem primates (plesiadapiforms), extending from the early Paleocene to late Eocene. We analyzed primate material from the late-middle Eocene of southern California that had initially been ascribed to cf. Phenacolemur shifrae. This material falls at the lowest end of the size range for the family. The Californian specimens also exhibit several dental features that are atypical for paromomyids, such as a strong paraconid on t... Read more

Sergi López-Torres, Mary T. Silcox, and Patricia A. Holroyd

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Two-fluid model to simulate metal powder bed fusion additive manufacturing

Two-fluid model to simulate metal powder bed fusion additive manufacturing

This paper reports our simulations of the metal powder fusion additive manufacturing process based on a two-fluid model. In simulations of metal behavior in which heat is applied by high-density energy sources (e.g., laser or electron beam), the aspects that need to be correctly modeled include boiling and evaporation, as well as melting and solidification. The potential of the two-fluid model to clarify numerous physical phenomena—deep penetration, plume generation, spatter generation due ... Read more

Noriko WATARI, Yuzuru OGURA, Noriko YAMAZAKI, Yukihiko INOUE, Keisuke KAMITANI, Yasuyuki FUJIYA, Masahiko TOYODA, Saneyuki GOYA, Toshiya WATANABE

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Structural Evolution of Highly Active Multicomponent Catalysts for Selective Propylene Oxidation

Structural Evolution of Highly Active Multicomponent Catalysts for Selective Propylene Oxidation

Multicomponent Bi-Mo-Fe-Co oxide catalysts prepared via flame spray pyrolysis were tested for selective propylene oxidation, showing high conversion (>70%) and selectivity (>85%) for acrolein and acrylic acid at temperatures of 330 ◦C. During extended time-on-stream tests (5–7 days), the catalysts retained high activity while undergoing diverse structural changes. This was evident on: (a) the atomic scale, using powder X-ray diffraction, Raman spectroscopy, X-ray absorption spectros... Read more

Paul Sprenger, Thomas L Sheppard, Jussi-Petteri Suuronen, Abhijeet Gaur, Federico Benzi and Jan-Dierk Grunwaldt

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RF-induced heating in tissue near bilateral DBS implants during MRI at 1.5 T and 3T: The role of surgical lead management

RF-induced heating in tissue near bilateral DBS implants during MRI at 1.5 T and 3T: The role of surgical lead management

Access to MRI is limited for patients with DBS implants due to safety hazards, including radiofrequency heating of tissue surrounding the leads. Computational models provide an exquisite tool to explore the multi-variate problem of RF implant heating. We used a computational approach to assess RF heating around tips of bilateral DBS leads during MRI at 1.5T and 3T using realistic DBS lead models. A substantial difference was found between the SAR and temperature rise at the tip of right and l... Read more

Laleh Golestanirad, John Kirsch, Giorgio Bonmassar, Sean Downs, Behzad Elahi, Alastair Martin, Maria-Ida Iacono, Leonardo M. Angelone, Boris Keil, Lawrence L. Wald, Julie Pilitsis

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Allometry and integration do not strongly constrain beak shape evolution in large-billed (Corvus macrorhynchos) and carrion crows (Corvus corone)

Allometry and integration do not strongly constrain beak shape evolution in large-billed (Corvus macrorhynchos) and carrion crows (Corvus corone)

Here, to evaluate the intensity of evolutionary constraints on avian beak shape more appropriately, we selected large billed (Corvus macrorhynchos) and carrion crows (Corvus corone) as study objects. These landbird species seem to experience selection pressures favoring a departure from an allometric trajectory. A landmark based geometric morphometric approach using three dimensional reconstructions of CT scan images revealed that only 45.4% of the total shape variation was explained by allom... Read more

Takeshi Yamasaki, Sou Aoki, Masayoshi Tokita

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In situ characterization of immiscible three-phase flow at the pore scale for a water-wet carbonate rock

In situ characterization of immiscible three-phase flow at the pore scale for a water-wet carbonate rock

X-ray micro-tomography is used to image the pore-scale configurations of fluid in a rock saturated with three phases – brine, oil and gas – mimicking a subsurface reservoir, at high pressure and temperature. We determine pore occupancy during a displacement sequence that involves waterflooding, gas injection and water re-injection. In the water-wet sample considered, brine occupied the smallest pores, gas the biggest, while oil occupied pores of intermediate size and is displaced ... Read more

Alessio Scanziani, Kamaljit Singh, Tom Bultreys, Branko Bijeljic, Martin J. Blunt

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Ultrastructural Characterization of Flashing Mitochondria

Ultrastructural Characterization of Flashing Mitochondria

Mitochondria undergo spontaneous transient elevations in matrix pH associated with drops in mitochondrial membrane potential. These mitopHlashes require a functional respiratory chain and the profusion protein optic atrophy 1, but their mechanistic basis is unclear. To gain insight on the origin of these dynamic events, we resolved the ultrastructure of flashing mitochondria by correlative light and electron microscopy. HeLa cells expressing the matrix-targeted pH probe mitoSypHer were screen... Read more

Manon Rosselin, Paula Nunes-Hasler, and Nicolas Demaurex

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High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation

High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation

HIV-1 maturation occurs via multiple proteolytic cleavages of the Gag polyprotein, causing rearrangement of the virus particle required for infectivity. (…) How individual cleavages contribute to changes in protein structure and interactions, and how the mature, conical capsid forms, are poorly understood. Here, we employed cryoelectron tomography to determine morphology and high-resolution CA lattice structures for HIV1 derivatives in which Gag cleavage sites are mutated. These analyse... Read more

Simone Mattei, Aaron Tan, Barbel Glass, Barbara Muller, Hans-Georg Krausslich, and John A. G. Briggs

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Partial dissolution of carbonate rock grains during reactive CO2-saturated brine injection under reservoir conditions

Partial dissolution of carbonate rock grains during reactive CO2-saturated brine injection under reservoir conditions

Our novel procedure of injecting oil after reactive transport has revealed previously unidentified (ghost) regions of partially-dissolved grains of carbonate rock. X-ray micro-tomography and FIB-SEM techniques were used to identify and resolve these ghost regions in three-dimensions at the nm- to µm-scale. Considering the solid part of the ghost regions as macro (bulk) pore space can result in the overestimation of porosity and permeability predi... Read more

Kamaljit Singh , Benaiah U. Anabaraonye , Martin J. Blunt , John Crawshaw

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Morphology of mitochondria in spatially restricted axons revealed by cryo-electron tomography

Morphology of mitochondria in spatially restricted axons revealed by cryo-electron tomography

Neurons project axons to local and distal sites and can display heterogeneous morphologies with limited physical dimensions that may influence the structure of large organelles such as mitochondria. Using cryo-electron tomography (cryo-ET), we characterized native environments within axons and presynaptic varicosities to examine whether spatial restrictions within these compartments influence the morphology of mitochondria. Segmented tomographic reconstructions revealed distinctive morphologi... Read more

Tara D. Fischer, Pramod K. Dash, Jun Liu, M. Neal Waxham

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Operative Anatomy of the Human Skull: A Virtual Reality Expedition

Operative Anatomy of the Human Skull: A Virtual Reality Expedition

The human cranial vault possesses an incredible, complex anatomical intricacy. Bridging the divide between 2-dimensional (2D) learning resources and the 3-dimensional (3D) world in which the anatomy becomes clinically relevant poses an intellectual challenge. Advances in computer graphics and modelling technologies have allowed increasingly accurate and representative resources to supplement cadaveric dissection specimens. To create accurate v... Read more

Benjamin K Hendricks, MD Akash J Patel, MD Jerome Hartman Mark F Seifert, PhD Aaron Cohen-Gadol, MD, MSc, MBA

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Metal-Organic Framework Crystal-Glass Composites

Metal-Organic Framework Crystal-Glass Composites

The majority of research into metal-organic frameworks (MOFs) focuses on their crystalline nature. However, in recent research the vitrification of a number of MOFs has been revealed. We propose that the solid-liquid phase transitions involved in MOF-glass formation can provide unique opportunities for the creation of a new class of functional, stable and porous composite materials. Described herein is the design, synthesis, and characterisation of novel metal-organic framework (MOF) crystal-... Read more

Jingwei Hou, Christopher W. Ashling, Sean M. Collins, Andraž Krajnc, Chao Zhou, Louis Longley, Duncan N. Johnstone, Philip A. Chater, Shichun Li, François-Xavier Coudert, David A. Keen, Paul A. Midgley, Gregor Mali, Vicki Chen, Thomas Bennett

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