Macropinosomes are key players in early shigella invasion and vacuolar escape in epithelial cells

Allon Weiner , Nora Mellouk , Noelia Lopez-Montero , Yuen-Yan Chang, CĂ©lia Souque, Christine Schmitt, Jost Enninga

Intracellular pathogens include all viruses, many bacteria and parasites capable of invading and surviving within host cells. Key to survival is the subversion of host cell pathways by the pathogen for the purpose of propagation and evading the immune system. The intracellular bacterium Shigella flexneri, the causative agent of bacillary dysentery, invades host cells in a vacuole that is subsequently ruptured to allow growth of the pathogen within the host cytoplasm…